In our latest question and answer, the pharmacist discusses whether or no NyQuil and also ZzzQuil can be taken together.

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Steve asked

Can you take it ZzzQuil and NyQuil together?


It is not safe to take ZzzQuil through NyQuilas both contain sedating "first generation" antihistamines. Utilizing both together would be taken into consideration a therapeutic duplication and can rise the risk of next effects.ZzzQuil contains diphenhydramine, the same active ingredient in Benadryl. NyQuil consists of doxylamine, additionally a sedating "first generation" antihistamine.

Interaction between NyQuil and ZzzQuilBoth NyQuil and also ZzzQuil save on computer sedating, "first generation" antihistamines. Making use of both would certainly be thought about a therapeutic duplication and also increases the hazard of side effects.Both drugs reason CNS (central worried system) depression, which may an outcome in a to decrease in blood pressure and severe drowsiness. In combination with other CNS depressants, dangerous side impacts such as respiratory depression room possible.Dosing Recommendations

Only take the NyQuil at bedtime if you require it for trouble sleepingandyou space experiencing multiple cold symptoms. NyQuil is a mix medication that contains the complying with ingredients:

Acetaminophen (analgesic)Dextromethorphan (cough suppressant)Doxylamine (sedating antihistamine)

ZzzQuil contains only doxylamine together its energetic ingredient and also should generally just be supplied as a sleep aid although it have the right to help details cold symptoms such together a runny nose and also post sleep drip.

While girlfriend shouldn"t take NyQuil and also ZzzQuil together, you have the right to take DayQuil and also ZzzQuil together.DayQuil consists of the following ingredients:

Acetaminophen (analgesic)Dextromethorphan (cough suppressant)Phenylephrine (nasal decongestant)

Taking DayQuil throughout the day and ZzzQuil in ~ bedtime is safe.


Do no take the ZzzQuil and Nyquil together because of them both containing a sedating very first generation antihistamine (diphenhydramine and doxylamine respectively).

It is vital to keep in mind that it is recommended that you execute not you use sleep aids for more than 2 weeks due to the fact that it can change your common sleep patterns. If girlfriend still cannot sleep there is no medication ~ the 2 weeks, please contact your doctor. Be sure to constantly read the ingredient on cold medication to ensure that you room not taking too lot of the same drug or two drugs treating the same symptom.

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Drink lot of of water when on these medications and also do no drive or operate machinery while taking NyQuil or ZzzQuil.